Abbot Nicholas (Zachariadis) was born in Cairo, Egypt of Greek parents. In 1963 the Zachariadis family emigrated to Australia. Finding two other Australians, with a similar sense of vocation, the three came to the United States in 1993 with a view to obtaining formation as Byzantine Catholic monks. This led to the foundation of Holy Resurrection Monastery in 1994. In 2000 Fr. Nicholas was elected Abbot of the monastery, and in 2005 was blessed to the position of Archimandrite by Bishop John Michael Botean.
In addition to his pastoral care of the monks of Holy Resurrection, Abbot Nicholas is also responsible for overseeing the nuns of Holy Theophany Monastery, a dependency of Holy Resurrection.